Laurent K. Verkoczy

The paper shows that B cell receptor signaling sets limits on the selection of functional mutations in antibodies, with mid-affinity antigens showing optimal neutralization.

This study identifies binding dynamics as a key factor in enhancing germinal center responses to HIV immunogens, improving the efficiency of somatic hypermutation and bnAb precursor activation.

This study shows that HIV Env trimers coupled to liposomes induce cross-neutralizing antibodies in NHPs that mimic human bNAbs targeting the Env trimer apex.

The paper tracks SARS-CoV-2 evolution in the U.S. from 2020 to early 2021, identifying mutational bursts, lineage signatures, and concerning Spike mutations that may impact vaccine efficacy.