Author

Tessa Dignum

Fred Hutch Cancer CenterORCID 0000-0003-1396-0919Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:scRNA-seq· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Barbara Varnum‐FinneyiD· 3 shared Brandon HadlandiD· 3 shared Cole TrapnelliD· 3 shared Cynthia Nourigat-Mckay· 3 shared Stacey Dozono· 3 shared Adam M. HeckiD· 2 shared Dana L. JacksoniD· 2 shared Irwin D. BernsteiniD· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersDevelopmental Biology

Barbara Varnum‐FinneyORCID

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3 papers

Recent·Most cited

Developmental BiologybioRxivPreprintMay 24, 2024

Multiplexed single cell transcriptomics optimizes mesodermal patterning and hemogenic endothelial output from murine embryonic stem cells

Barbara Varnum‐Finney, Adam M. Heck, Sanjay R Srivatsan…·Brandon Hadland

This study uses sci-Plex to analyze how Activin and BMP4 gradients affect mesoderm patterning and hemogenic endothelial cell production in mouse embryonic stem cells.

1 citation

mousescRNA-seq

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Developmental BiologyCell ReportsPeer-reviewedSep 1, 2021

Multipotent progenitors and hematopoietic stem cells arise independently during the endothelial to hematopoietic transition in the early mouse embryo

Tessa Dignum, Barbara Varnum‐Finney, Sanjay R Srivatsan…·Brandon Hadland

The paper shows that multipotent progenitors and HSC arise from distinct HE populations during mouse embryogenesis, identified through clonal assays and single-cell transcriptomics.

112 citationstop 1%

mousescRNA-seq

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Developmental BiologybioRxivPreprintJan 25, 2021

Engineering a niche supporting haematopoietic stem cell development using integrated single cell transcriptomics

Brandon Hadland, Barbara Varnum‐Finney, Stacey Dozono…·Irwin D. Bernstein

The paper identifies key signaling molecules involved in HSC development by analyzing single-cell transcriptomics data from AGM-derived cells and uses them to engineer a supportive niche for HSC generation.

5 citations

mousescRNA-seq

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