Author

Irwin D. Bernstein

University of WashingtonORCID 0000-0003-0795-3392Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Barbara Varnum‐FinneyiD· 3 shared Brandon HadlandiD· 3 shared Cole TrapnelliD· 3 shared Cynthia Nourigat-Mckay· 3 shared Dana L. JacksoniD· 3 shared Shahin RafiiiD· 3 shared Stacey Dozono· 3 shared Adam M. HeckiD· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersDevelopmental Biology

Barbara Varnum‐FinneyORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Developmental BiologybioRxivPreprintJun 1, 2023

Differentiation latency, cell division symmetry, and dormancy signatures define fetal liver HSCs at single cell resolution

Takashi Ishida, Juliane I Mercoli, Adam M. Heck…·Brandon Hadland

The paper identifies rare fetal liver HSCs with unique features like differentiation latency and dormancy signatures using single cell RNA-sequencing and a niche-mimicking culture platform.

DOI 10.1101/2023.06.01.543314

mousescRNA-seq

𝕏 PostBluesky

Developmental BiologyCell ReportsPeer-reviewedSep 1, 2021

Multipotent progenitors and hematopoietic stem cells arise independently during the endothelial to hematopoietic transition in the early mouse embryo

Tessa Dignum, Barbara Varnum‐Finney, Sanjay R Srivatsan…·Brandon Hadland

The paper shows that multipotent progenitors and HSC arise from distinct HE populations during mouse embryogenesis, identified through clonal assays and single-cell transcriptomics.

112 citationstop 1%

mousescRNA-seq

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Developmental BiologybioRxivPreprintJan 25, 2021

Engineering a niche supporting haematopoietic stem cell development using integrated single cell transcriptomics

Brandon Hadland, Barbara Varnum‐Finney, Stacey Dozono…·Irwin D. Bernstein

The paper identifies key signaling molecules involved in HSC development by analyzing single-cell transcriptomics data from AGM-derived cells and uses them to engineer a supportive niche for HSC generation.

5 citations

mousescRNA-seq

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