Dana L. Jackson

Embryo-scale single-cell chemical transcriptomics reveals dependencies between cell types and signaling pathways

The paper uses single-cell RNA-seq to study signaling pathway dependencies in zebrafish pectoral fin development, identifying new cell types and signaling relationships.

Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart

The paper uses single-nucleus ATAC-Seq and RNA-Seq to analyze age and sex differences in human heart cells, identifying gene expression and chromatin changes linked to these factors.

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

The paper uses a combined single-cell genetic and chemical screening platform to analyze kinase dependencies in glioblastoma response to targeted therapy, identifying adaptive signaling and potential combination therapies.

Proteostasis governs differential temperature sensitivity across embryonic cell types

The paper uses single-cell RNA-seq to study temperature sensitivity in zebrafish embryos, finding that notochord sheath cells are particularly vulnerable due to protein misfolding.

Differentiation latency, cell division symmetry, and dormancy signatures define fetal liver HSCs at single cell resolution

The paper identifies rare fetal liver HSCs with unique features like differentiation latency and dormancy signatures using single cell RNA-sequencing and a niche-mimicking culture platform.

Single-cell landscape of nuclear configuration and gene expression during stem cell differentiation and X inactivation

The paper integrates single-cell RNA-seq, ATAC-seq, and Hi-C data to study nuclear configuration and gene expression changes during stem cell differentiation and X inactivation, revealing discrete structural changes and delayed chromatin compaction.

Multipotent progenitors and hematopoietic stem cells arise independently during the endothelial to hematopoietic transition in the early mouse embryo

The paper shows that multipotent progenitors and HSC arise from distinct HE populations during mouse embryogenesis, identified through clonal assays and single-cell transcriptomics.

Engineering a niche supporting haematopoietic stem cell development using integrated single cell transcriptomics

The paper identifies key signaling molecules involved in HSC development by analyzing single-cell transcriptomics data from AGM-derived cells and uses them to engineer a supportive niche for HSC generation.

Visual Cell Sorting: A High-throughput, Microscope-based Method to Dissect Cellular Heterogeneity

This paper introduces a method to physically separate live cells based on visual phenotypes and uses it to study nuclear localization sequences and paclitaxel resistance in human cancers.

On the design of CRISPR-based single cell molecular screens

The paper identifies a major issue with CRISPR-based single cell screens due to guide-barcode swapping and presents an optimized method to improve accuracy.

Chromatin accessibility dynamics of myogenesis at single cell resolution

The paper introduces Cicero, a statistical method to link regulatory elements to target genes using single-cell chromatin accessibility data, and applies it to study myogenesis.