Judith Hagenbuchner

Naloxone, a NOX2 inhibitor, largely restored mitochondrial networks and curbed a pro-fibrotic signature in LCHADD/VLCADD patient fibroblasts, and rescued impaired vessel formation in 3D bioprinted vascularized constructs.

This paper develops an optical tomography method to reconstruct 3D motion and structure of multiple-scattering samples under rotational actuation, achieving isotropic resolution for biomedical applications.

The paper shows that tafazzin deficiency in Barth Syndrome protects against ferroptosis by altering mitochondrial cardiolipin metabolism, affecting VDAC function and reducing ROS availability for ferroptosis.