Michael J. Ausserlechner

Naloxone as mitochondrial phenotype rescuer in a 3D bioprinted LCHADD/VLCADD model

Naloxone, a NOX2 inhibitor, largely restored mitochondrial networks and curbed a pro-fibrotic signature in LCHADD/VLCADD patient fibroblasts, and rescued impaired vessel formation in 3D bioprinted vascularized constructs.

Amphibian-derived peptide analog TB_KKG6K: A powerful drug candidate against Candida albicans with anti-biofilm efficacy

This study identifies TB_KKG6K, an amphibian-derived peptide, as a potent antifungal agent effective against Candida albicans planktonic cells and biofilms, with no adverse effects on standard antifungal drugs.

Unraveling the YAP1-TGFβ1 axis: a key driver of androgen receptor loss in prostate cancer-associated fibroblasts

This study identifies the YAP1-TGFβ1 axis as a driver of androgen receptor loss in prostate cancer-associated fibroblasts, showing its role in promoting aggressive disease and resistance to therapy.

Optical tomography reconstructing 3D motion and structure of multiple-scattering samples under rotational actuation

This paper develops an optical tomography method to reconstruct 3D motion and structure of multiple-scattering samples under rotational actuation, achieving isotropic resolution for biomedical applications.