Nicholas J. McGlincy

This study investigates how eIF4E depletion affects amino acid metabolism and reveals novel translational control mechanisms involving GCN4 and PCL5.

The paper develops a genome-scale CRISPRi guide library for yeast, validates its coverage through fitness defects, and improves guide measurement accuracy with barcoding and in vitro transcription.

The paper introduces a neural network model to predict translation elongation rates and validates it by designing synonymous variants that match predicted protein output in yeast.