Kevin Kamanyi Marucha

This study investigates the role of the EIF4E1-4EIP cap-binding complex in translation repression in Trypanosoma brucei, showing that 4EIP stabilizes EIF4E1 and recruits TUT3, but NOT complex may be involved in 4EIP function.

The paper describes two new Trypanosoma brucei brucei strains with minimal in vitro passage and reports gene copy-number changes associated with culture adaptation.

This study shows that PUF3 is not essential for Trypanosoma brucei growth or differentiation in vitro but may have a role in the invertebrate host or gene expression regulation.

This study identifies ZC3H20 and ZC3H21 as mRNA stabilizing factors in Trypanosoma brucei, showing they regulate membrane and mitochondrial protein mRNAs during developmental transitions.

This study shows that 4EIP suppresses mRNA translation in Trypanosoma brucei and is required for differentiation to stumpy forms.