Joaquím Roca

This study shows DNA catenation is essential for sister chromatid cohesion in budding yeast and metazoan chromosomes, as it provides force resistance necessary for accurate chromosome segregation.

The paper measures DNA linking number differences restrained by nucleosomes in yeast, showing variation based on genomic location and demonstrating topological memory of nucleosomes.

The paper shows condensin creates a short negatively supercoiled DNA loop during ATP usage, which may merge with an extruding loop.

The paper identifies 116 gene clusters in S. cerevisiae that respond to topological stress, showing distinct genomic locations and functional characteristics.