Joana Segura

Slow RNAPII elongation enhances naive-pluripotency rewiring while preserving replication fork speed

The paper shows that slowing RNAPII elongation during cell state transitions enhances naive pluripotency acquisition while maintaining replication fork speed.

EpiFlow: multidimensional single-cell epigenetic profiling by spectral flow cytometry

EpiFlow quantifies 16 epigenetic markers per cell using spectral flow cytometry, showing broad applicability across species and biological processes.

Nucleosomal DNA has topological memory

The paper measures DNA linking number differences restrained by nucleosomes in yeast, showing variation based on genomic location and demonstrating topological memory of nucleosomes.

Condensin pinches a short negatively supercoiledDNA loop during each round of ATP usage

The paper shows condensin creates a short negatively supercoiled DNA loop during ATP usage, which may merge with an extruding loop.