Monica Dus

This study identifies E93 as a retained developmental transcription factor that maintains neuronal identity and function in adult Drosophila circuits.

This study shows that pyruvate kinase deficiency causes axonal and synaptic degeneration in Drosophila, linking metabolic changes to neurodegeneration and axonal protection through specific signaling pathways.

This study shows that dArc genes in Drosophila melanogaster regulate sugar reward valuation through capsid-mediated intercellular communication, affecting associative learning and reward valuation.

This study identifies HisCl1 as a regulator of gustatory habituation in Drosophila sweet taste neurons, showing it reduces spike frequency adaptation and mediates sugar ingestion.

This study shows that N6-adenosine methylation regulates insulin mRNA translation in D. melanogaster, leading to metabolic phenotypes and conserved m6A signatures in vertebrate insulin mRNAs.

This study shows how the metabolic enzyme OGT regulates chromatin accessibility and transcription in Drosophila gustatory neurons to mediate sensory adaptations to a high sugar diet.

This study shows that a high sugar diet reprograms the epigenetic state of sweet taste neurons in Drosophila, reducing sweet sensation and promoting obesity, with some changes persisting after diet normalization.

The paper shows that high sugar diets impair satiation by reducing central processing of sweet taste in Drosophila through PAM-β2 dopaminergic neurons.