Guanghui Zhu

This study identifies IGF1R-dependent neutrophil reprogramming in the bone marrow microenvironment during prostate cancer metastasis and shows its therapeutic targeting potential.

TMEformer is a spatial deep learning framework that models tumor microenvironment dependencies and enables virtual perturbation analysis using spatial transcriptomics data.

The paper identifies CD4+CXCR5+PD-1- Tfh cells as prognostic and predictive biomarkers for R-CHOP therapy response in DLBCL using single-cell RNA sequencing and multiplex IHC.