Sujun Chen

This study identifies IGF1R-dependent neutrophil reprogramming in the bone marrow microenvironment during prostate cancer metastasis and shows its therapeutic targeting potential.

TMEformer is a spatial deep learning framework that models tumor microenvironment dependencies and enables virtual perturbation analysis using spatial transcriptomics data.

This paper identifies the EZH2-TTP-mTORC1 axis as a driver of phenotypic plasticity and therapeutic vulnerability in prostate cancer, showing that combined inhibition of EZH2 and PI3K/mTORC1 improves anti-tumor activity.

The paper identifies essential circRNAs in human cancer cells and introduces FunCirc, a database of functional circRNAs across cancer cell lines and tissues.

This study identifies HNRNPM as a splicing factor critical for prostate cancer cell growth by regulating splicing fidelity and circRNA biogenesis, suggesting it as a therapeutic target.