Neutrophils orchestrate pre-metastatic immunosuppressive bone marrow remodeling during prostate cancer metastasis
Yingkui Tang, Xuan Zhou, Duocai Li, Yadan Liu, Guanghui Zhu, Jian Wang, Xiumei Wu, Da Zhong, Ziyi Li, Haojie Huang, Bin-Zhi Qian, Yuanyuan Zhang, Jianru Xiao, Zhiying Yue, Sujun Chen, Shancheng Ren
This study identifies IGF1R-dependent neutrophil reprogramming in the bone marrow microenvironment during prostate cancer metastasis and shows its therapeutic targeting potential.
bioRxiv · Oct 9, 2026 · PreprintCancer Biology