Author

Hao Kong

Sichuan UniversityORCID 0000-0002-8683-5580Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:imaging· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:mechanistic / dynamical model· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Hong JiangiD· 3 shared Xiangji WuiD· 3 shared Hubing ShiiD· 2 shared Lang CheniD· 2 shared Nengwen KeiD· 2 shared Panpan MaiD· 2 shared Qiang WeiiD· 2 shared Qingxin YangiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Hong JiangORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer

Wenyan Xie, Xin Yu, Qingxin Yang, Nengwen Ke, Ping Wang, Hao Kong, Xiangji Wu, Panpan Ma, Lang Chen, Jie Yang, Xiuqin Feng, Yuan Wang, Hubing Shi, Lu Chen, Yunhua Liu, , Hong Jiang

This study identifies PYK2 as an immunomechanical checkpoint governing monocyte-to-macrohage differentiation in PDAC, showing its role in mechanotransduction and improved immunotherapy response.

Cancer Discovery · May 8, 2025Peer-reviewedImmunology

Multi-modal profiling identifies CD4+CXCR5+PD-1- Tfh cells as prognostic and predictive biomarkers for response to R-CHOP therapy in human DLBCL

Sisi Yu, Hao Kong, Huaichao Luo, Xingzhong Zhao, Guanghui Zhu, Xiuqin Feng, Jie Yang, Xiangji Wu, Yu Dai, Chunwei Wu, James Q. Wang, Dan Cao, Yang Xu, Hong Jiang, Ping Wang

The paper identifies CD4+CXCR5+PD-1- Tfh cells as prognostic and predictive biomarkers for R-CHOP therapy response in DLBCL using single-cell RNA sequencing and multiplex IHC.

bioRxiv · Oct 10, 2024 · PreprintImmunology

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

Hao Kong, Xiangji Wu, Qingxin Yang, Qian Sun, Xin Yu, Yu Dai, Chun-Wei George Wu, Dai Xie, Lang Chen, Panpan Ma, Siqi Dai, Chong Chen, Peng Mi, Xiaodong Feng, Yong Li Peng, , Hong Jiang

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

bioRxiv · Jul 24, 2024 · PreprintImmunology