Richard V. Pearse

The paper introduces a proteomic tool to identify protein markers for human microglial states and validates their utility in purification and differentiation.

The paper uses iPSC-derived astrocytes to study genetic risk factors for Alzheimer's disease, finding concordant molecular changes in both astrocytes and brain tissue.

This study shows that INPP5D/SHIP1 regulates inflammasome activation in human microglia, with reduced INPP5D leading to increased IL-1β and IL-18 secretion.

This study shows that SORL1 loss reduces APOE levels specifically in neurons and astrocytes, linking SORL1 and APOE to Alzheimer's disease risk through distinct pathways.

The paper identifies cell-type and cell-subtype specific eQTLs in aging human cortex, revealing variant effects on gene expression and disease associations.

The paper identifies JMJD6 and other key drivers of Alzheimer's disease using predictive network analysis and validates their effects on amyloid-beta and tau pathology in human neurons.

The paper quantifies mosaic loss of chromosome Y (LOY) in brain cells across multiple datasets and finds microglia are most affected by LOY, with associated gene expression changes linked to aging and neurodegeneration.