Author

Laura Alejandra Ariza Orellano

University of Massachusetts Chan Medical SchoolORCID 0000-0003-1509-8488Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Chunhui ZengiD· 1 shared Jiann‐Jyh LaiiD· 1 shared Jiyun ZhuiD· 1 shared Kenneth L. RockiD· 1 shared Matthew S. BogyoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

Chunhui ZengORCID

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1 paper

Recent·Most cited

ImmunologyCommunications MedicinePeer-reviewedApr 17, 2026

A broad cathepsin inhibitor blocks crystal-stimulated inflammasome-dependent and -independent inflammation, and gout arthritis

Laura Alejandra Ariza Orellano, Chunhui Zeng, Jiyun Zhu…·Jiann‐Jyh Lai

This study shows that broad-spectrum cathepsin inhibitors block crystal-induced inflammation and gout arthritis by inhibiting both inflammasome-dependent and -independent pathways that generate IL-1β.

2 citations

mouseproteomics

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