Adam K. Hedger

CRYPTID-exon identifies cryptic exons in human RNA-seq data, showing their impact on mRNA stability and gene expression through ASO targeting.

This study designs and tests optimized oligonucleotide inhibitors for APOBEC3 enzymes, showing improved potency and nuclease stability compared to previous inhibitors.

This paper introduces a chemical adenylation method using formamide that achieves >90% yield for RNA sequencing ligation adaptors, improving scalability and reducing cleanup steps.

SisterC is a method to distinguish inter- and intra-sister chromatid interactions using BrdU labeling and Hi-C, revealing centromere alignment and cohesin-mediated loops.