Zongcai Ruan

BigNeuron benchmarks automatic neuron reconstruction algorithms using gold standard annotations and image quality metrics, showing that consensus methods outperform individual algorithms.

The paper introduces MorphoHub, a platform for generating petabyte-scale multi-morphometry data, enabling high-quality analysis of neuronal structures in whole brain datasets.

Complete morphologies of 1,708 neurons, sparsely labelled and imaged whole-brain with fMOST, expose region-specific long-range projection rules and finer diversity than current transcriptomic subtypes capture.

The paper introduces TeraVR, a virtual reality system for precise 3-D neuronal morphology reconstruction in whole mouse brains, enabling collaborative and efficient annotation of complex neuronal structures.