Kan Yang

This study identifies de novo variants in Chinese ASD trios, finding that ASD without DD/ID has fewer disruptive variants and novel risk genes not in existing databases.

This study identifies a SENP1 mutation in mice that causes core autistic-like symptoms by disrupting the SENP1-FMRP axis in the retrosplenial agranular cortex.

This study shows that CREST mutations in mice lead to neuroinflammatory responses and motor defects similar to ALS, revealing a molecular mechanism involving the CREST-BRG1 complex and cytokine expression.