Shifang Shan

An orthogonal near-infrared optical switch for wireless neuromodulation in freely behaving mice

This paper introduces a Dual-NIR Switch using near-infrared light to control neuronal activity in mice without sustained illumination, enabling on-demand neuromodulation.

Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins

This paper develops ProAPOBECs, engineered cytidine deaminases fused with PUF proteins, for effective RNA base editing in the brain, correcting mutations and reducing autistic-like behaviors in mice.

Srcap Haploinsufficiency Induced Autistic-Like Behaviors in Mice through Disruption of Satb2 Expression

This study shows that Srcap haploinsufficiency in mice causes autistic-like behaviors by reducing Satb2 expression, which can be reversed with Satb2 gene therapy.

Whole-brain in vivo base editing reverses autistic-like behaviors in mice

This paper demonstrates whole-brain in vivo base editing in mice to reverse autistic-like behaviors by correcting a mutation in the MEF2C gene.

SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice

This study identifies a SENP1 mutation in mice that causes core autistic-like symptoms by disrupting the SENP1-FMRP axis in the retrosplenial agranular cortex.

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice

This study identifies CNTNAP3 mutations in ASD cohorts and shows its role in synaptic development and social behavior in mice.

Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice

This study shows that CREST mutations in mice lead to neuroinflammatory responses and motor defects similar to ALS, revealing a molecular mechanism involving the CREST-BRG1 complex and cytokine expression.