Mengdi Wang

AutoScreen improves gene prioritization in functional genomics by integrating AI agents for pre-screen design and post-screen analysis, achieving higher hit recovery and precision than existing methods.

This study shows nanovibrational stimulation preferentially enhances osteogenic responses in zebrafish without significantly affecting other tissues.

CellCUT improves spatial transcriptomics by accurately segmenting cells and assigning transcripts using nuclear images, outperforming existing methods in diverse tissues and challenging data conditions.

This study identifies cyclical compression loading as critical for normal joint morphogenesis in zebrafish, showing that dynamic mechanical stimuli, not static compression, regulate joint shape and growth.

This study uses computational modeling to show that growth orientation, not growth rate, primarily drives jaw joint morphogenesis in larval zebrafish.

This study identifies de novo variants in Chinese ASD trios, finding that ASD without DD/ID has fewer disruptive variants and novel risk genes not in existing databases.

The paper identifies molecularly distinct neuronal subtypes in the superior colliculus that mediate predator avoidance and prey capture behaviors through separate transcriptomic codes.

This study creates a single-cell transcriptome atlas of human and macaque retinas across ages, revealing species-specific molecular features and age-related changes in cell types and disease associations.

The paper develops FIST analysis to study light-sensitive neurons in mouse V1, finding specific gene expression patterns associated with light responsiveness.