This study shows miR-29a reprograms exhausted CD8 T cells into a stem-like state, enhancing their effector function and response to checkpoint inhibitors.

DOI 10.64898/2026.05.25.727439

humanbulk RNA-seq

𝕏 PostBluesky

BioinformaticsBioinformaticsPeer-reviewedAug 28, 2019

Unification of miRNA and isomiR research: the mirGFF3 format and the mirtop API

Thomas Desvignes, Phillipe Loher, Karen L Eilbeck…·Lorena Pantano

The paper introduces mirGFF3, a standardized format for miRNA/isomiR analysis, and mirtop, a tool to convert outputs into this format, enabling data sharing and comparative analysis.

58 citations

bulk RNA-seqstatistical model

𝕏 PostBluesky

Systems BiologyCancer ResearchPeer-reviewedApr 17, 2019

Systems-Level Analysis Of 32 TCGA Cancers Reveals Disease-Dependent tRNA Fragmentation Patterns And Very Selective Associations With Messenger RNAs And Repeat Elements

Aristeidis G. Telonis, Phillipe Loher, Rogan G. Magee…·Isidore Rigoutsos

The paper analyzes tRNA fragments (tRFs) across 32 cancer types, identifying disease-specific patterns and associations with mRNAs and repeat elements.

90 citationstop 4%

humanbulk RNA-seq

𝕏 PostBluesky

BioinformaticsNucleic Acids ResearchPeer-reviewedFeb 15, 2017

The presence or absence alone of miRNA isoforms (isomiRs) successfully discriminate amongst the 32 TCGA cancer types

Aristeidis G. Telonis, Rogan G. Magee, Phillipe Loher…·Isidore Rigoutsos

The paper shows that binary isomiR profiles can accurately classify 32 TCGA cancer types with high sensitivity and low false discovery rate.

224 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky