Alejandro V. Villarino

Altered Purinergic Signaling and CD8+ T Cell Dysregulation in STAT3 GOF Syndrome

This study identifies altered purinergic signaling and CD8+ T cell dysregulation in STAT3 GOF syndrome, showing partial normalization with JAK inhibitors.

MicroRNA-29a enhances and preserves stem-like CD8 T cell differentiation by regulating master epigenetic circuits of exhaustion.

This study shows miR-29a reprograms exhausted CD8 T cells into a stem-like state, enhancing their effector function and response to checkpoint inhibitors.

Asymmetry and redundancy of STAT5 paralogs across CD8+ T cell differentiation states

The paper shows STAT5B is dominant and functionally distinct from STAT5A in CD8+ T cells, revealing redundancy and asymmetry in their roles during differentiation.

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

B12 promotes gut dysbiosis and an inflammatory microenvironment that potentiates Tet2-deficient hematopoiesis.

This study shows that B12 supplementation promotes gut dysbiosis and inflammation, which enhances myelopoiesis in Tet2-deficient mice, suggesting a microbiome-mediated mechanism for clonal hematopoiesis.

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

The paper investigates two STAT5B mutations in T cell leukemias, showing one causes gain-of-function and the other loss-of-function, with distinct impacts on immune cell populations and transcriptional activity.

Preserved suppressive function despite loss of Foxp3: insights into the identity of regulatory T cells

This study shows that regulatory T cells can maintain suppressive function and a Treg signature even when Foxp3 expression is lost in Th2-driven disease models.