Jinzhao Wang

The paper uses single-cell chromatin accessibility to identify cell type- and state-specific regulatory programs associated with type 2 diabetes risk.

The paper identifies T2D risk variants in pancreatic progenitor-specific enhancers and shows their role in regulating developmental genes involved in pancreas morphogenesis.

The paper shows FOXA pioneer factors prime some enhancers but require lineage-specific TFs to activate others, influencing endodermal organ fate decisions.

The paper identifies miRNAs that promote cell cycle exit and differentiation of human pancreatic endocrine cells through regulatory networks.

The paper shows LSD1-mediated enhancer silencing limits RA signaling duration during endocrine cell development by suppressing persistent enhancer activity.