Author

Nicholas K. Vinckier

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2

Frequent Co-Authors

Allen WangiD· 4 shared Maike SanderiD· 4 shared Jinzhao WangiD· 3 shared Joshua ChiouiD· 3 shared Bing ReniD· 2 shared Hung-Ping ShihiD· 2 shared Kelly A. FrazeriD· 2 shared Kyle J. GaultoniD· 2 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersGenomics

Allen WangORCID

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Author profile →

4 papers

Recent·Most cited

A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

Ryan J. Geusz, Allen Wang, Dieter K. Lam, Nicholas K. Vinckier, Konstantinos–Dionysios Alysandratos, David A. Roberts, Jinzhao Wang, Samy Kefalopoulou, Yunjiang Qiu, Joshua Chiou, Kyle J. Gaulton, Bing Ren, Darrell N. Kotton, Maike Sander

The paper shows FOXA pioneer factors prime some enhancers but require lineage-specific TFs to activate others, influencing endodermal organ fate decisions.

bioRxiv · Aug 28, 2020 · PreprintGenomics

A network of microRNAs acts to promote cell cycle exit and differentiation of human pancreatic endocrine cells

Wen Long Jin, Francesca Mulas, Bjoern Gaertner, Yinghui Sui, Jinzhao Wang, Ileana Matta, Chun Zeng, Nicholas K. Vinckier, Allen Wang, Kim-Vy Nguyen-Ngoc, Joshua Chiou, Klaus H. Kaestner, Kelly A. Frazer, Andrea C. Carrano, Hung-Ping Shih, Maike Sander

The paper identifies miRNAs that promote cell cycle exit and differentiation of human pancreatic endocrine cells through regulatory networks.

iScience · Nov 1, 2019Peer-reviewedDevelopmental Biology

LSD1-mediated enhancer silencing enables endocrine cell development through attenuation of retinoic acid signalling.

Nicholas K. Vinckier, Nisha A. Patel, Allen Wang, Jinzhao Wang, Hung-Ping Shih, Jianxun Wang, Ulupi S. Jhala, Michael G. Rosenfeld, Christopher W. Benner, Maike Sander

The paper shows LSD1-mediated enhancer silencing limits RA signaling duration during endocrine cell development by suppressing persistent enhancer activity.

bioRxiv · Aug 1, 2019 · PreprintDevelopmental Biology

Pancreatic islet chromatin accessibility and conformation defines distal enhancer networks of type 2 diabetes risk

William W. Young Greenwald, Joshua Chiou, Jian Yan, Yunjiang Qiu, Ning Dai, Allen Wang, Naoki Nariai, Anthony Aylward, Jee Yun Han, Nikita Kadakia, Laura Regué, Mei-Lin Okino, Frauke Drees, Dana Krämer, Nicholas K. Vinckier, , Kyle J. Gaulton

The paper identifies distal enhancer networks in pancreatic islets associated with type 2 diabetes risk by integrating chromatin accessibility, conformation, and genetic data.

Nature Communications · May 7, 2019Peer-reviewedGenomics