Author

Ryan J. Geusz

University of California San DiegoORCID 0000-0002-4897-9305Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:fine-mapping· 1

Frequent Co-Authors

Joshua ChiouiD· 3 shared Kyle J. GaultoniD· 3 shared Maike SanderiD· 3 shared Allen WangiD· 2 shared Bing ReniD· 2 shared Jinzhao WangiD· 2 shared Samy KefalopoulouiD· 2 shared Yunjiang QiuiD· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenomics

Joshua ChiouORCID

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3 papers

Recent·Most cited

Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes risk

Joshua Chiou, Ryan J. Geusz, Mei-Lin Okino, Jee Yun Han, Michael Miller, Rebecca L. Melton, Elisha Beebe, Paola Benaglio, Serina Huang, Katha Korgaonkar, Sandra Heller, Alexander Kleger, Sebastian Preißl, David U. Gorkin, Maike Sander, Kyle J. Gaulton

This study combines large-scale GWAS and single-cell epigenomics to identify cell type-specific mechanisms of type 1 diabetes risk.

Nature · May 19, 2021Peer-reviewedGenetics

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

Ryan J. Geusz, Allen Wang, Joshua Chiou, Joseph J. Lancman, Nichole Wetton, Samy Kefalopoulou, Jinzhao Wang, Yunjiang Qiu, Jian Yan, Anthony Aylward, Bing Ren, P. Duc Si Dong, Kyle J. Gaulton, Maike Sander

The paper identifies T2D risk variants in pancreatic progenitor-specific enhancers and shows their role in regulating developmental genes involved in pancreas morphogenesis.

eLife · Feb 5, 2021Peer-reviewedGenomics

A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

Ryan J. Geusz, Allen Wang, Dieter K. Lam, Nicholas K. Vinckier, Konstantinos–Dionysios Alysandratos, David A. Roberts, Jinzhao Wang, Samy Kefalopoulou, Yunjiang Qiu, Joshua Chiou, Kyle J. Gaulton, Bing Ren, Darrell N. Kotton, Maike Sander

The paper shows FOXA pioneer factors prime some enhancers but require lineage-specific TFs to activate others, influencing endodermal organ fate decisions.

bioRxiv · Aug 28, 2020 · PreprintGenomics