Anna Köferle

This paper introduces ARTi, a method using synthetic shRNAs to achieve precise and controllable RNAi for gene suppression.

The paper identifies novel paralog gene dependencies in cancer, including sex chromosome-encoded gene pairs, suggesting therapeutic strategies for tumors with Y-chromosome loss.

The paper uses scRNA-seq and imaging to study gene expression heterogeneity in fission yeast under different environmental conditions, revealing how gene expression varies during growth and stress responses.