Ralph A. Neumüller

This study identifies BAP18 as a substrate of MAGE-A3/6, showing its degradation promotes cancer cell migration in both cell lines and human tissues.

This study shows that DUSP4 knockdown causes cell cycle arrest and halts tumor growth in BRAF V600E mutant colorectal cancer models but does not lead to tumor regression.

The paper identifies genetic vulnerabilities linked to transcription factor activities in cancer cell lines using CRISPR knockout data and validates targets associated with TEAD1.

This paper introduces ARTi, a method using synthetic shRNAs to achieve precise and controllable RNAi for gene suppression.

The paper shows how floorplate organiser forms autonomously in neural tube organoids through BMP-mediated cluster competition and FOXA2 dynamics.

The paper identifies novel paralog gene dependencies in cancer, including sex chromosome-encoded gene pairs, suggesting therapeutic strategies for tumors with Y-chromosome loss.