Colm McDonald

The paper examines longitudinal white matter changes in early psychosis using diffusion tensor imaging and finds no significant group differences or associations with symptom progression, but links antipsychotic medication dose to lower fractional anisotropy.

This study analyzes structural brain network changes in bipolar disorder, finding widespread connectivity disruptions linked to illness severity and medication use.

The paper introduces a scalable toolkit for 3D surface-based brain analysis, demonstrating its utility in mapping subcortical shape variations across 21 international samples.

The paper evaluates factors affecting brain-age prediction models using structural neuroimaging data from 35,683 individuals, finding optimal model performance with no site harmonization, age-binning, and a sample size of over 1,600.

The paper identifies MEF2C direct target genes enriched for schizophrenia and cognitive function genes, showing their involvement in neurogenesis and mitochondrial function.

This study maps microstructural abnormalities along white matter tracts in bipolar disorder using multisite diffusion MRI tractometry and identifies significant differences in fractional anisotropy between BD patients and controls.

This study uses diffusion MRI and BUAN to map microstructural differences in white matter tracts between bipolar disorder patients and controls, finding altered Fractional Anisotropy in specific pathways.

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

The paper analyzes sex differences in brain structure variability across the lifespan using a large dataset, finding greater male variability in subcortical volumes, cortical surface area, and thickness in most regions.

This study identifies DNA methylation changes in blood samples from psychosis patients, including treatment-resistant schizophrenia, and links them to biological age, smoking, and cellular composition.

The paper identifies an excess of rare loss-of-function and missense mutations in voltage-gated sodium channels and synaptic genes associated with schizophrenia using large-scale sequencing and meta-analysis.