Maged Gomaa Hemida

Integrated epidemiological and genomic analysis of some respiratory Bovine Coronavirus isolates reveals circulation of GIIb strains and ongoing viral evolution in U.S. Cattle (2020-2025)

The paper analyzes respiratory BCoV isolates from U.S. cattle 2020-2025, identifying GIIb strains and amino acid substitutions suggesting ongoing viral evolution.

Isolation and molecular characterization of an enteric isolate of the Genotype-I Bovine coronavirus with notable mutations in the receptor binding domain of the spike glycoprotein and deletion downstream the RNA binding domain of the nucleocapsid protein.

This study isolates and characterizes a new BCoV isolate, identifying mutations in the spike protein and deletions in the nucleocapsid gene, with implications for viral pathogenesis and immune evasion.

The Ex Vivo Infection of the Peripheral Bovine Mononuclear Cells (PBMCs) and the Bovine Spleen Cells with the Bovine Coronavirus (BCoV) Induced a Differential Expression of the Host Cytokine Genes Profiles and Modulates the Virus Replication

This study infects bovine PBMCs and spleen cells with BCoV, showing differential cytokine gene expression and effects on T-cell populations that may support virus replication.

Applications of some artificial intelligence tools in the drug design of some compounds targeting the main viral protease of the Feline Infectious Peritonitis Virus (FIPV) in cats

This study uses in-silico tools to identify antiviral compounds targeting FIPV-MPro, finding N3, Sofosbuvir, and methotrexate as top inhibitors.

The dual actions of the host miRNA-16a in restricting Bovine coronavirus (BCoV) replication through targeting host cell Furin and in enhancing the host immune response.

This study identifies miRNA-16a as a host factor that inhibits BCoV replication by targeting Furin and enhances immune response, suggesting its potential as an antiviral therapy.