Author

Connie Hou

The University of Texas MD Anderson Cancer CenterORCID 0000-0003-1669-0061Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Dacheng MaiD· 1 shared Ella Bedford· 1 shared Han XuiD· 1 shared Helen H. WangiD· 1 shared Jinzhuang DouiD· 1 shared Liang ZhangiD· 1 shared Martin DepkeniD· 1 shared Oscar David VillarrealiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperSystems Biology

Dacheng MaORCID

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1 paper

Recent·Most cited

Systems BiologyNature CommunicationsPeer-reviewedJan 25, 2022

Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity

Rongjie Fu, Wei He, Jinzhuang Dou…·Han Xu

This study systematically identifies sequence determinants of CRISPR/Cas9 specificity by analyzing off-target effects of 1,902 gRNAs on 13,314 targets, revealing three key factors and developing a predictive tool.

55 citationstop 5%

CRISPR screenstatistical model

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