Dacheng Ma

The paper introduces SaprotHub, a platform that simplifies training and sharing of protein language models, enabling non-experts to build and collaborate on customized models.

This paper introduces a novel antigen-inducible promoter to enhance CAR-T cell activation in low-immunogenic environments, showing improved cytokine expression and T cell proliferation.

This study systematically identifies sequence determinants of CRISPR/Cas9 specificity by analyzing off-target effects of 1,902 gRNAs on 13,314 targets, revealing three key factors and developing a predictive tool.