Helen H. Wang

Fetal context conveys heritable protection against MLL-rearranged leukemia that depends on MLL3

The paper shows fetal exposure to MLL::ENL creates a heritable leukemia-resistant state by altering hematopoietic progenitor behavior, which can be overcome by MLL3 inactivation or cooperating mutations.

Transcriptomic reprogramming screen identifies SRSF1 as rejuvenation factor

This study identifies SRSF1 as a rejuvenation factor through transcriptomic reprogramming, showing it improves cellular function and is linked to longevity.

Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity

This study systematically identifies sequence determinants of CRISPR/Cas9 specificity by analyzing off-target effects of 1,902 gRNAs on 13,314 targets, revealing three key factors and developing a predictive tool.

GuidePro: A multi-source ensemble predictor for prioritizing sgRNAs in CRISPR/Cas9 protein knockouts

GuidePro integrates multiple predictive methods to prioritize sgRNAs for CRISPR/Cas9 protein knockouts, showing consistent performance across datasets.