Richard Ortega

This study uses synchrotron XRF imaging to show manganese accumulates in the Golgi and postsynapses of neurons and astrocytes, with astrocytes taking up more manganese and reducing neuronal uptake.

This study shows that labile Fe(II) is stored in lysosomes and transported along axons and dendrites in hippocampal neurons, with a method to quantify its distribution.

The paper investigates wild-type SOD1 misfolding in Parkinson's disease using proteomics and a novel mouse model, showing mismetallation and altered post-translational modifications contribute to pathology and dopamine neuron degeneration.