Daniel Choquet

ALPINE enables 3D single-molecule imaging and tracking of endogenous proteins in native environments with high resolution and dynamic quantification.

This study uses synchrotron XRF imaging to show manganese accumulates in the Golgi and postsynapses of neurons and astrocytes, with astrocytes taking up more manganese and reducing neuronal uptake.

The paper shows that βII and βIII spectrin paralogues form a dual system in the dendritic MPS, with structural redundancy and paralogue-specific regulation.

The paper develops a nanobody-gold conjugate for dual light-electron microscopy to label GFP-tagged synaptic proteins with high specificity and nanoscale resolution.

The paper develops paralog-specific intrabodies for PSD-93 and SAP102 to study excitatory synapse organization.

The paper investigates how AMPAR surface diffusion and desensitization contribute to frequency-dependent synaptic adaptation during high-frequency stimulation.

The paper develops synthetic binders specific to PSD-95 for imaging endogenous proteins with minimal impact on function and compatibility with super-resolution techniques.

This study investigates the role of hippocampal synaptic plasticity in memory consolidation during ripple activities, finding that it is essential during consolidation but not encoding or recall.

This study investigates how 4.1N and SAP97 differentially regulate phases of GluA1 AMPA receptor intracellular transport and exocytosis under basal and cLTP conditions.

This study uses a knock-in mouse model to monitor and manipulate AMPA receptor mobility, showing its role in synaptic plasticity and memory formation.

The paper shows MDGAs delay excitatory synapse development by altering neuroligin behavior through fast diffusion and reduced mobility.

The paper shows that CaMKII activation leads to persistent liquid-liquid phase separation with GluN2B, forming stable postsynaptic assemblies that enhance synaptic transmission and memory formation.

This study shows that constitutive ghrelin receptor activity regulates AMPA receptor trafficking and synaptic plasticity, and its inhibition impairs memory.

This study shows that AMPAR trafficking-dependent LTP drives cortical remapping and behavioral recovery after partial sensory loss in mice.

The paper investigates nanoscale synaptic changes during two LTD protocols, showing NMDAR-dependent LTD reorganizes PSD-95 to enhance synaptic facilitation.

This study shows that impaired AMPA receptor surface diffusion contributes to synaptic plasticity and memory deficits in Huntington’s disease, and that tianeptine can restore these functions.

The paper shows that neuroligin-1 alignment with AMPA receptor nanodomains is critical for synaptic transmission efficiency, as disrupting this alignment reduces transmission.