Zeynep Dokuzluoglu

This study identifies endogenous SMN protein heterogeneity as a determinant of motor neuron vulnerability and resilience, showing that SMN levels dynamically influence neuronal fate in disease models.

The paper shows that TFEB activation restores lysosomal function and improves motor neuron survival in SMA, highlighting its potential as a therapeutic target.

The paper introduces a method to generate spinal motor neurons with diverse axial identities in human spinal cord organoids, enhancing their utility for studying neural development and disease.

This study uses an isogenic human iPSC model to show altered neural progenitor and motor neuron markers in SMA, suggesting developmental defects may contribute to neuronal death.

This study shows HB-EGF promotes HBC expansion and OSN regeneration in zebrafish OE after injury, while inhibiting HB-EGF/EGFR signaling delays repair.