Fabian Rost

This study shows that inducing stemness in human macrophages prevents IFNγ-induced exhaustion, enhancing their antitumour activity and persistence in vivo.

This study identifies endogenous SMN protein heterogeneity as a determinant of motor neuron vulnerability and resilience, showing that SMN levels dynamically influence neuronal fate in disease models.

This study shows that transplanted human photoreceptors integrate and mature better in mildly degenerated retinas than severely degenerated ones, depending on the retinal microenvironment.

The paper uses cerebral organoids from patients with actin mutations to show that altered cleavage plane orientation in ventricular zone progenitors leads to microcephaly.

The paper shows coordinated gene expression variability reflects cell regulatory states using scRNA-seq data and machine learning.

The paper investigates Notch-induced lineage conversion in mammary basal cells using single-cell transcriptomics and shows that proliferation is essential for the transition to luminal progenitors.

The paper introduces a method to generate spinal motor neurons with diverse axial identities in human spinal cord organoids, enhancing their utility for studying neural development and disease.

This study investigates how social environment affects Alzheimer's disease progression in App-NL-G-F mice, showing social deficits precede pathology and linking microglia activation to neuroinflammation and neurogenesis.

The paper investigates cell lineage relationships in zebrafish fin regeneration using single-cell RNA sequencing and lineage tracing, revealing compartmentalized osteoblast and blastema contributions to bone formation.

The paper uses single-cell RNA sequencing to study zebrafish retina regeneration, identifying transcriptional changes and fate decisions in Muller glia and progenitors.

This study maps β-cell regeneration in zebrafish using single-cell transcriptomics, identifying hybrid β/δ cells as key contributors to diabetes recovery.

The paper identifies Lgr5+ hepatoblasts as bi-potent liver progenitors that contribute to liver development and reside at the apex of the embryonic hepatoblast hierarchy.