Cyril Lagger

This study uses spike-in normalization to analyze age-related changes in gene expression across mouse cell types, finding decreased mRNA content in non-immune cells and increased in immune cells, along with reduced gene expression and shared regulatory processes between ageing and proliferation arrest.

The paper identifies senescent cell heterogeneity by analyzing stress response enrichment in bulk RNA-seq data and proposes a model based on Stress Response Modules.

The paper introduces scAgeCom, an atlas of age-related intercellular communication changes in 23 mouse tissues, using the scDiffCom package to analyze single-cell RNA-seq data from two consortia.