Federica Luppino

A combined transcriptional and dynamic roadmap of single human pancreatic endocrine progenitors reveals proliferative capacity and differentiation continuum

The paper uses single-cell RNA-seq and live imaging to study NEUROG3 dynamics in human pancreatic endocrine progenitors, revealing differences in expression timing and proliferation patterns compared to mice.

DeMAG predicts the effects of variants in clinically actionable genes by integrating structural and evolutionary epistatic features

DeMAG improves variant classification by integrating structural and evolutionary epistatic features, reducing false positives and improving accuracy for clinically actionable genes.