Christoph Zechner

The paper shows that simple thresholding on 3D distance measurements from live-cell microscopy leads to inaccurate estimates of chromatin looping parameters, and proposes noise-aware methods for better accuracy.

This study calibrates Micro-C with live imaging to determine absolute chromatin looping probabilities in mouse cells, finding most loops occur at low frequencies.

This study uses live-cell imaging to show that enhancer-promoter interactions drive gene activation through transient contacts of ~25-42 nanometers.

This study shows that anisotropic stretch biases actin fiber orientation in Hydra cell aggregates during self-organization from a disordered state.

This paper shows that concentration buffering and noise reduction in phase separating systems are distinct concepts, neither of which is required or sufficient for the other.

The paper uses single-cell RNA-seq and live imaging to study NEUROG3 dynamics in human pancreatic endocrine progenitors, revealing differences in expression timing and proliferation patterns compared to mice.

The paper uses live imaging to show that retinal progenitors make both deterministic and probabilistic fate decisions, with stochasticity increasing under developmental stress.

This study demonstrates intercellular communication and feedback in synthetic multicellular systems using cell-free expression systems in droplet interface bilayers.

The paper analyzes how gene promoters exhibit different dynamic behaviors in response to varying transcription factor contexts using single-cell measurements and a statistical method.

The paper investigates the effects of communication in a network of cells on dynamic concentration-sensing, showing that super-Poissonian dynamics reduce MSE with more neighbors, while Poissonian dynamics only speed up convergence.

The paper investigates how variability in Hox transcription factor concentration is controlled during development, finding that an auto-regulatory switch reduces variability by changing the balance of activating and repressing isoforms.