Anne Grapin‐Botton

Pancreatic progenitor cells respond to laminar shear stress with transcriptomic changes, accompanied by reduced YAP1 activity

This study investigates how pancreatic progenitor cells respond to fluid shear stress, finding transcriptomic changes and reduced YAP1 activity.

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease

This study identifies HNF1B and NPHP3 mutations as causes of a new pancreatic disease, ciliogenic pancreatopathy, characterized by acinar atrophy and adipose replacement, and links ciliary dysfunction to pancreatic dysfunction in humans and mice.

Control of lumen geometry and topology by the interplay between pressure and cell proliferation rate in pancreatic organoids

The paper investigates how lumen morphology in pancreatic organoids is controlled by the balance between cell proliferation rate and lumen pressure, showing that lower pressure and faster proliferation lead to more complex lumen shapes.

Predicting Organoid Morphology Through a Phase Field Model: Insights into Cell Division and Lumenal Pressure

This paper uses a phase field model to predict organoid morphology by simulating cell division and lumenal pressure, identifying key parameters that determine shape and structure.

GEQO biosensors for absolute analyte quantification in single cells

The paper introduces GEQO biosensors for absolute analyte quantification in single cells without requiring specialized equipment, showing they account for buffering and retain time trace information.

The interplay between lumen pressure and cell proliferation determines organoid morphology in a multicellular phase field model

This paper develops a multicellular phase field model to simulate organoid morphology by integrating lumen pressure and cell proliferation, revealing how these factors determine organoid shapes and phenotypes.

A combined transcriptional and dynamic roadmap of single human pancreatic endocrine progenitors reveals proliferative capacity and differentiation continuum

The paper uses single-cell RNA-seq and live imaging to study NEUROG3 dynamics in human pancreatic endocrine progenitors, revealing differences in expression timing and proliferation patterns compared to mice.

Apical restriction of the planar cell polarity component VANGL in pancreatic ducts is required to maintain epithelial integrity

The paper shows that apical restriction of VANGL in pancreatic ducts is essential for epithelial integrity, with loss of restriction causing cell death and extrusion.

Notch Controls Multiple Pancreatic Cell Fate Regulators Through Direct Hes1-mediated Repression

This study identifies direct Hes1 target genes in pancreatic progenitor cells, revealing Notch signaling's role in repressing tip cell fate through repression of key regulators like Ptf1a and Gata4.