Byung Ho Lee

This study shows that cancer cells adjust their nuclear volumes and proliferation rates during transitions between single and multicellular states in tumor spheroids.

The paper investigates how lumen morphology in pancreatic organoids is controlled by the balance between cell proliferation rate and lumen pressure, showing that lower pressure and faster proliferation lead to more complex lumen shapes.

This paper uses a phase field model to predict organoid morphology by simulating cell division and lumenal pressure, identifying key parameters that determine shape and structure.

This paper develops a multicellular phase field model to simulate organoid morphology by integrating lumen pressure and cell proliferation, revealing how these factors determine organoid shapes and phenotypes.

The paper uses single-cell RNA-seq and live imaging to study NEUROG3 dynamics in human pancreatic endocrine progenitors, revealing differences in expression timing and proliferation patterns compared to mice.