PhysiologybioRxivPreprint
Dysferlin Regulates Cardiac T-tubule Structure and Excitation-contraction Coupling in Isolated Cardiac Myocytes at Rest and in Response to Acute Hypo-osmotic Stress and is Protective Against Arrhythmias in Langendorff-perfused Hearts
Callum J Quinn, C. Booth, Kerri L. M. Smith…·Katharine M. Dibb
This study shows dysferlin is critical for maintaining cardiac T-tubule structure and EC coupling, and its loss increases arrhythmia risk under stress and during aging.
DOI 10.1101/2025.08.20.671306