Andrew W. Trafford

Enhanced hypoxic ventilatory response is accompanied by a decrease in carotid body mitochondrial oxygen affinity in heart failure

This study investigates changes in carotid body mitochondrial function in heart failure, finding decreased oxygen affinity and increased oxidative stress.

Carotid body mitochondria exhibit normal oxygen affinity despite COX4I2 enrichment

This study measures mitochondrial oxygen affinity in carotid body and left ventricular tissue, finding slightly lower but not significantly different affinity in the carotid body, suggesting other factors, like NO, influence oxygen sensing.

Cardiac microtubules mediate transverse (t)-tubule growth and homeostasis

This study shows that cardiac microtubules regulate t-tubule formation and maintenance through BIN1-CLIP-170 and dynein mechanisms, impacting Ca handling and contractile function.

Acute sildenafil administration reduces susceptibility to induced atrial fibrillation in sheep

This study shows that acute sildenafil administration reduces atrial fibrillation susceptibility in sheep by prolonging refractory periods and altering electrophysiological properties.

Increased calcium spark frequency and variability of action potential duration precede early after depolarisations in isolated ventricular myocytes

This study shows that increased action potential duration variability and calcium sparks precede early afterdepolarisations in ventricular myocytes, suggesting calcium handling instability as a key mechanism for drug-induced arrhythmias.

Developmental Hypoxia Increases Susceptibility to Cardiac Ventricular Arrhythmias in Adult Offspring

This study shows that fetal hypoxia increases susceptibility to ventricular arrhythmias in adult offspring by altering excitation-contraction coupling.

Dysferlin Regulates Cardiac T-tubule Structure and Excitation-contraction Coupling in Isolated Cardiac Myocytes at Rest and in Response to Acute Hypo-osmotic Stress and is Protective Against Arrhythmias in Langendorff-perfused Hearts

This study shows dysferlin is critical for maintaining cardiac T-tubule structure and EC coupling, and its loss increases arrhythmia risk under stress and during aging.

Peptide location fingerprinting identifies species- and tissue-conserved structural remodelling of proteins as a consequence of ageing and disease

The paper uses peptide location fingerprinting to identify age- and disease-related structural changes in proteins across species and tissues.

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.