Kerri L. M. Smith

Developmental Hypoxia Increases Susceptibility to Cardiac Ventricular Arrhythmias in Adult Offspring

This study shows that fetal hypoxia increases susceptibility to ventricular arrhythmias in adult offspring by altering excitation-contraction coupling.

Sex, Stress and the Heart: Long-term Cardiovascular Effects of Embryonic Metabolic Disruption

This study examines how embryonic hypoxia and hypothermia affect cardiovascular structure and function in chickens, revealing sex-specific differences in mitochondrial morphology and ventricular hypertrophy.

Dysferlin Regulates Cardiac T-tubule Structure and Excitation-contraction Coupling in Isolated Cardiac Myocytes at Rest and in Response to Acute Hypo-osmotic Stress and is Protective Against Arrhythmias in Langendorff-perfused Hearts

This study shows dysferlin is critical for maintaining cardiac T-tubule structure and EC coupling, and its loss increases arrhythmia risk under stress and during aging.

Ribosomal modification by BUD23 drives selective translational control over energy state and metabolic health

This study identifies BUD23 as a regulator of energy homeostasis by controlling translation of mitochondrial and lipogenic mRNAs, linking ribosomal modification to metabolic health.