Joachim Nielsen

This paper develops a deep learning model to automate glycogen localization in TEM images of skeletal muscle, achieving high accuracy and efficiency compared to manual methods.

This study shows that Rac1 deficiency in muscle reduces mitochondrial function and fatty acid metabolism, leading to muscle wasting and highlights potential therapeutic targets for age-related muscle decline.

This study finds that high-intensity interval training increases mitochondrial cristae density in type 2 diabetes patients, with no baseline differences in cristae density compared to other groups.

This study uses chemogenetics to induce mitochondrial H2O2 in skeletal muscle and shows it causes dose-dependent atrophy without structural damage.

This study examines how high-altitude exposure affects mitochondrial subcellular distribution, ultrastructure, and respiratory capacity in sea-level residents.

This study finds that male elite endurance athletes have greater lipid droplet-mitochondria contact in skeletal muscle compared to recreationally active individuals, linked to higher organelle densities and specific size-related associations.

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.