Adam J. Fletcher

The paper shows that alternative splicing of the OAS2 gene generates two antiviral proteins with distinct target specificities and mechanisms.

This study shows ZNFX1 uses a two-component ubiquitin circuit to trap viral RNA, linking its function to antiviral immunity.

This study identifies HOIP and linear ubiquitin chains as critical for TRIM21-mediated ADIN by recruiting VCP, enhancing virus neutralization.