Doménica Marchese

Multi-omic profiling of pleural effusions: a reservoir-incubator for non-invasive insights into tumor heterogeneity

This study presents the first comprehensive single-cell and multi-omic atlas of pleural effusions, revealing disease-specific immune landscapes and tumor heterogeneity.

Latent plasticity of the human pancreas across development, health, and disease.

The paper constructs a single-cell multiomics atlas of the human pancreas across development, health, and T2D, identifying plastic cell states and lineage trajectories.

SiteCELL enables on-site PBMCs purification and cryopreservation for immune single cell profiling of diverse ancestries

SiteCELL enables on-site purification and cryopreservation of PBMCs for immune single cell profiling, performing as well as Ficoll density gradient in both lab and rural settings.

Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas.

This paper benchmarks multimodal single-cell data integration methods to improve kidney reference atlas quality by identifying adaptive states and rare cell types.

Decoding the immune response in leptomeningeal disease through single-cell sequencing of cerebrospinal fluid

The paper uses single-cell sequencing and spatial transcriptomics to compare immune responses in leptomeningeal disease with other CNS disorders, identifying disease-specific immune environments and progression mechanisms.

FixNCut: Single-cell genomics through reversible tissue fixation and dissociation

FixNCut is a reversible fixation and dissociation method that preserves RNA integrity and cellular composition in human and mouse tissues, enabling robust single-cell and spatial analyses.

Sampling artifacts in single-cell genomics cohort studies

The paper identifies sampling artifacts in single-cell genomics and proposes solutions to mitigate them in cohort studies.