Xuechun Shen

This study analyzes the genetic diversity of the deep sea, linking protein structures to genetic variants and identifying biotechnologically relevant features.

The paper identifies a novel Cas12a variant, BvCas12a, with high specificity and engineers variants with broader PAM compatibility and improved editing efficiency.

The paper presents a comprehensive compendium of fully circularized human gut bacterial genomes and reveals how mobile genetic elements drive functional diversity with therapeutic implications.

PAMPHLET predicts PAM sequences for CRISPR-Cas systems by expanding spacer data through homology searches, achieving high accuracy validated by experimental methods.

CRISPR-Detector detects, visualizes, and annotates genome-wide mutations from CRISPR/Cas gene editing events with improved speed, scalability, and accuracy.